Had the same problem running on Windows 7, after hours of messing with it I finally got it working.
Did a complete Uninstall of "Avolites Titan PC Suite 10.0" though Control Panel>Uninstall a Program
Completely Disabled Windows Firewall Control Panel>System And Security>Windows Firewall>Turn Windows Firewall on and off.
Restarted computer.
Ran "Avolites Titan PC Suite v10.0 Setup"
Restarted Computer.
Downloaded and installed "Take Ownership"
http://www.howtogeek.com/howto/windows- ... -in-vista/Ran "Take Ownership" program by right clicking on C>Users>"username">AppData>Roaming>Avolites folder and selecting "Take Ownership"
Then Run "Take Ownership" program by right clicking on C>Programfiles(x86)>Avolites folder and select "Take ownership" and let CMD program run till in closes itself (may take a few minutes)
Restarted Computer
Ran Avolites Simulator and HOLY SHIT!!! It finally just stopped pulsing "Starting Titan" and went to the Activation Screen!!!!!!
Not exactly sure if all of these steps are necessary, but for anyone also having this problem, I feel for you and after I got it to work I didn't want to jinx it by trying it differently.
I really hope this helps some of you from ripping your hair out like I was. Happy programming Y'all : )